Victoria Stodden writes:
The reproducibility of published findings is becoming a hot topic. From reports in the popular press to congressional activity, and from scholarly society engagement to academic publications and editorials, there has been an upsurge in attention to this issue. I will offer some explanations of the concept itself, suggest reasons why this topic is suddenly front and center, and outline ways the field of statistics can contribute to resolving the underlying issues all this attention is bringing to the fore.
The concept of reproducibility is getting attention in mainstream discussions. On October 19, The Economist magazine opened a Briefing on “Unreliable Research” with a quote from Nobel Laureate Daniel Kahneman, “I see a train wreck looming,” referring to the irreproducibility of certain psychological experiments . On October 27, the Los Angeles Times informed us that “Science has lost its way” since it cannot be relied upon to generate “verifiable facts” . Reproducibility is also discussed in scholarly communications [3–8]. In 2011 Science Magazine began requiring authors to remit code and data upon request for articles it publishes , and in April of this year Nature published an editorial entitled “Reducing our irreproducibility,” in which they encouraged researchers to make raw data available and follow a checklist for reporting methods, while extending the methods section to accommodate . These are just a few examples.
These discussions have emerged from a wide variety of scientific disciplines, each with different practices that contextualize the meaning of reproducibility differently. At one end of the spectrum is the traditional scientific notion of experimental researchers capturing descriptive information about (non-computational) aspects of their research protocols and methods, labeled empirical reproducibility. For example, a spotlight was placed on empirical cancer research in 2011 when Bayer HealthCare in Germany could not validate the published findings upon which 67 of their in-house projects were based . In 2012 Amgen’s attempts to replicate studies were published, and they claimed to have only been able to do so for 6 of 53 articles . These results rocked the research community and, in part, prompted Nature to encourage authors to communicate their methods more completely. These efforts could be described as attempts to adhere more closely to the long-established standards of communication, as reflected in the title of the Nature editorial of March 2012: “Must try harder.” 
At the other end of the spectrum are the very different concerns arising from research communities that have adopted computational methods, labeled computational reproducibility [5, 14-16]. These voices call for new standards of scientific communication that include digital scholarly objects such as data and code, asserting that the traditional research article alone fails to capture the computational details and other information necessary for others to replicate the findings. Irreproducible computational results from genomics research at Duke University crystallized attention to this issue . As a result the Institute of Medicine of the National Academies published a report in 2012 recommending new standards for clinical trials approval for computational tests arising from omics-based research . The report recommended for the first time that the software associated with a computational test be fixed at the beginning of the approval process, and made “sustainably available.” In December of 2012 a workshop on “Reproducibility in Computational and Experimental Mathematics” produced recommendations regarding information to include with publications of computational findings, including access to code, data, and implementation details [19-22]. The distinction between these two types of reproducibility is important in order to understand their sources and appropriate solutions.
The reasons, and therefore the remedies, differ depending on the type of reproducibility. In the case of computational reproducibility, issues arises from an exogenous shift in the scientific research process itself — the broad use of computation — and the proposed solution seeks to extend the standards of transparency established for empirical science to the computational aspects of the research. In the case of empirical reproducibility, which lacks an obvious change to the underlying research process, we must look further.
Several reasons have been postulated for the reported lack of reproducibility in empirical research, beyond mistakes or misconduct such as outright fraud or falsification. Small study size, inherently small effect sizes, early or novel research without previously established evidence, poorly designed protocols that permit flexibility during the study, conflicts of interest, or the trendiness of the research topic have been previously suggested as contributing to irreproducibility in the life sciences . Others include social reasons such as publication bias toward positive findings or established authors, or ineffective peer review . Statistical biases may stem from misapplied methodology, incorrect use of p-values, a failure to adjust for multiple comparisons, or overgeneralization of the results. [25-27]. Statistical methods have varying degrees of sensitivity to perturbations in the underlying data, and can produce different findings in replication contexts [28-29]. Many fields have been inundated with vast amounts of data, often collected in novel ways or from new sources, rapidly shifting the context within which statistical methods must operate. Developing a research agenda within the statistical community to address issues surrounding reproducibility is imperative.
New Research Directions
Addressing issues of reproducibility through improvements to the research dissemination process is important, but insufficient. Research directions that would contribute to resolving these new methodological questions could include: new measures to assess the reliability and stability of empirical inferences, including developing new validation measures; expanding the field of uncertainty quantification to develop measures of statistical confidence and a better understanding of sources of error, especially when large multi-source datasets or massive simulations are involved [30-31]; and detecting biases arising from statistical reporting conventions. In addition, advances in understanding how to best archive software and data for replication purposes, and the development of best research practices are essential. This is not an exhaustive list, but intended to jumpstart thinking about the importance a research agenda in reproducibility as it relates to developing, asserting, and interpreting statistical findings.
For students and others wishing to learn more about reproducible research further information is available my wiki page http://wiki.stodden.net/. For an example of teaching reproducible research, see Gary King’s course website, where students replicate findings from a published article . I have taught a similar course at Columbia .
 “Unreliable Research: Trouble at the Lab,” The Economist, Oct 19, 2013. http://www.economist.com/news/briefing/21588057-scientists-think-science-self-correcting-alarming-degree-it-not-trouble
 “Science has lost its way, at a big cost to humanity,” Los Angeles Times, Oct 27, 2013. http://www.latimes.com/business/la-fi-hiltzik-20131027,0,1228881.column
 D. L. Donoho, A. Maleki, I. U. Rahman, M. Shahram and V. Stodden, Reproducible Research in Computational Harmonic Analysis, Computing in Science and Engineering, vol. 11, no. 1, pp. 8-18, Jan./Feb. 2009, doi:10.1109/MCSE.2009.15
 Ioannidis JPA (2005) Why Most Published Research Findings Are False. PLoS Med 2(8): e124. doi:10.1371/journal.pmed.0020124 http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.0020124
 Stodden, V., “Reproducible Research: Tools and Strategies for Scientific Computing,” July/August 2012 (vol. 14 no. 4), pp. 11-12. http://www.computer.org/csdl/mags/cs/2012/04/mcs2012040011-abs.html
 R. D. Peng, Reproducible Research in Computational Science, Science, Vol. 334, p. 1226-1227, 2011, doi:10.1126/science.1213847
 Sandve GK, Nekrutenko A, Taylor J, Hovig E (2013) Ten Simple Rules for Reproducible Computational Research. PLoS Comput Biol 9(10): e1003285. doi:10.1371/journal.pcbi.1003285
 Brian A. Nosek, Jeffrey R. Spies and Matt Motyl, “Scientific Utopia II. Restructuring Incentives and Practices to Promote Truth Over Publishability,” Perspectives on Psychological Science November 2012 vol. 7 no. 6, 615-631. http://pps.sagepub.com/content/7/6/615.abstract
 Brooks Hanson, Andrew Sugden, Bruce Alberts, “Making Data Maximally Available,” Science, Vol. 331 no. 6018 p. 64, 2011. doi:10.1126/science.1203354 http://www.sciencemag.org/content/331/6018/649.full
 Announcement: Reducing our irreproducibility, Nature 496, 398, 25 April 2013. doi:10.1038/496398a http://www.nature.com/news/announcement-reducing-our-irreproducibility-1.12852
 Florian Prinz, Thomas Schlange, Khusru Asadullah, “Believe it or not: how much can we rely on published data on potential drug targets?,” Nature Reviews Drug Discovery 10, 712 (September 2011) | doi:10.1038/nrd3439-c1 http://www.nature.com/nrd/journal/v10/n9/full/nrd3439-c1.html
 C. Glenn Begley & Lee M. Ellis, “Drug development: Raise standards for preclinical cancer research,” Nature 483, 531–533 (29 March 2012) doi:10.1038/483531a http://www.nature.com/nature/journal/v483/n7391/full/483531a.html
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 King, Gary. 1995. “Replication, Replication.” Political Science and Politics 28: 443–499. http://gking.harvard.edu/files/abs/replication-abs.shtml
 LeVeque, R. J., 2006, “Wave propagation software, computational science, and reproducible research,” Proc. International Congress of Mathematicians, (M Sanz-Sole, J. Soria, J. L. Varona and J. Verdera, eds.) Madrid, August 22-30, 2006, pp. 1227-1254. http://faculty.washington.edu/rjl/pubs/icm06/icm06leveque.pdf
 David L. Donoho, Arian Maleki, Inam Ur Rahman, Morteza Shahram, Victoria Stodden, “Reproducible Research in Computational Harmonic Analysis”, IEEE Computing in Science and Engineering, 11(1), January 2009, p.8-18. http://www.computer.org/csdl/mags/cs/2009/01/mcs2009010008-abs.html
 Kaiser, J., “Panel Calls for Closer Oversight of Biomarker Tests,” ScienceInsider, March 23, 2012. http://news.sciencemag.org/education/2012/03/panel-calls-closer-oversight-biomarker-tests
 “Evolution of Translational Omics: Lessons Learned and the Path Forward,” Institute of Medicine Report, National Academies of Science, 2012. http://www.iom.edu/reports/2012/evolution-of-translational-omics.aspx
 ICERM Workshop, “Reproducibility in Computational and Experimental Mathematics,” December 10-14, 2012. http://icerm.brown.edu/tw12-5-rcem
 ICERM Workshop Report, Appendix D, http://stodden.net/icerm_report.pdf
 D. H. Bailey, J. M. Borwein, Victoria Stodden, “Set the Default to ‘Open’,” Notices of the American Mathematical Society, June/July 2013. http://www.ams.org/notices/201306/rnoti-p679.pdf
 Victoria Stodden, Jonathan Borwein, and David H. Bailey, “ ‘Setting the Default to Reproducible’ in Computational Science Research,” SIAM News, June 3, 2013. http://www.siam.org/news/news.php?id=2078
 Francis, G. (2012). The psychology of replication and replication in psychology. Perspectives on Psychological Science, 7, 585– 594. http://pps.sagepub.com/content/7/6/585.abstract
 J. Berger, “Reproducibility of Science, P-values and Multiplicity,” SBSS Webinar, Oct 4, 2012.
 Gelman A., “The connection between varying treatment effects and the crisis of unreplicable research: A Bayesian perspective,” forthcoming in the Journal of Management, 2014. http://www.stat.columbia.edu/~gelman/research/published/bayes_management.pdf
 Simmons J., Nelson L., Simonsohn U. (2011) “False-Positive Psychology: Undisclosed Flexibility in Data Collection and Analysis Allow Presenting Anything as Significant”, Psychological Science, V22(11), 1359-1366. http://papers.ssrn.com/sol3/papers.cfm?abstract_id=1850704
 Yu, B., “Stability,” Bernoulli, Volume 19, Number 4 (2013), 1484-1500. http://projecteuclid.org/DPubS?service=UI&version=1.0&verb=Display&handle=euclid.bj/1377612862
 Chinghway Lim, Bin Yu, “Estimation Stability with Cross Validation (ESCV),” 2013. http://arxiv.org/abs/1303.3128
 National Research Council Report, “Assessing the Reliability of Complex Models: Mathematical and Statistical Foundations of Verification, Validation, and Uncertainty Quantification,” 2012. http://www.nap.edu/catalog.php?record_id=13395
 National Research Council Report, “Frontiers in Massive Data Analysis,” 2013. http://www.nap.edu/catalog.php?record_id=18374
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